Actively Recruiting
Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult
Led by Region Stockholm · Updated on 2026-05-14
200
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
Sponsors
R
Region Stockholm
Lead Sponsor
K
Karolinska Institutet
Collaborating Sponsor
AI-Summary
What this Trial Is About
High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery. In specific groups of patients such as the obese and after upper abdominal surgery the results are contradictive. However, there is lack of evidence if HFNO in the general high-risk patient after abdominal and non-cardiac thoracic surgery can reduce the prevalence of PPC, hypoxaemia and escalation of therapy. Therefore, the investigators aim to compare the use of HFNO with conventional oxygen therapy (COT) in high-risk patients after abdominal and non-cardiac thoracic surgery regarding postoperative pulmonary complications.
CONDITIONS
Official Title
Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older scheduled for elective abdominal (laparotomy or laparoscopy), open abdominal vascular, or non-cardiac thoracic surgery under general anesthesia lasting over 3 hours
- Must meet at least two of the following: age over 65 years, BMI over 30, preoperative oxygen saturation below 95%, scheduled for lobectomy or pulmonary segment resection, respiratory infection in the last month, preoperative anemia (hemoglobin below 100) or severe hypoalbuminemia (below 20 g/L), current or former smoker with over 30 pack-years, pulmonary disease or obstructive sleep apnea syndrome, heart failure, clinical frailty (CFS 4)
You will not qualify if you...
- Not suitable for postoperative high-flow nasal oxygen as decided by study staff or anesthetist (e.g., total nasal obstruction, skull fracture, facial injuries)
- Pregnancy
- Unable to understand study information or sign informed consent
- Unable to participate in postoperative treatment
- Planned delayed extubation in intensive care
- Preoperative non-invasive ventilation due to respiratory failure or requiring higher care than a regular ward
AI-Screening
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Trial Site Locations
Total: 1 location
1
Karolinska University Hospital
Stockholm, Sweden
Actively Recruiting
Research Team
I
Ida-Maria Forsberg, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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