Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia.
O Edafe, R Antakia, N Laskar...
https://pubmed.ncbi.nlm.nih.gov/24402815Actively Recruiting
Age: 18Years - 75Years
All Genders
ID07428057
A Ten-Year Cohort Study of Clinical and Surgical Predictors for Hypocalcemia Post-Thyroidectomy
Led by Minia University · Updated on 2026-03-06
600
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to identify factors that predict low calcium levels after thyroid surgery, a common complication affecting 20-50% of patients. The study looks at patients who had thyroid removal surgery at Minia University Hospital from 2014 to 2024. Researchers want to understand which demographic, clinical, laboratory, and surgical details are linked to both temporary and long-lasting low calcium levels to improve patient care and management. The study reviews medical records of adults who underwent total, subtotal, or completion thyroidectomy. It collects information including age, gender, body mass index, thyroid disease type, surgery details, calcium and hormone levels, and pathology reports. Statistical methods will identify key risk factors, and a risk prediction score will be developed and tested. Subgroups based on surgery extent and surgeon experience will also be analyzed. Participants' surgical and post-surgical data will be examined, including calcium and parathyroid hormone measurements over six months following surgery. Researchers will track calcium and vitamin D supplementation, hospital stay length, emergency visits, and readmissions related to low calcium. The main outcome is the incidence of post-surgery hypocalcemia within six months. Findings aim to guide better patient counseling, monitoring, and preventive strategies during and after thyroid surgery.
CONDITIONS
Brief Title
Postoperative Hypocalcemia After Thyroidectomy
Who Can Participate
Age: 18Years - 75Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older at time of surgery
- Underwent thyroidectomy at Minia University Hospital
- Availability of medical records with complete surgical and postoperative data
- Documented serum calcium levels measured postoperatively
- Minimum follow-up of 6 months postoperatively or documented outcome status
You will not qualify if you...
- Age less than 18 years at time of surgery
- Preoperative hypocalcemia (serum calcium <8.0 mg/dL or ionized calcium <1.0 mmol/L)
- Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism)
- Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate <60 mL/min/1.73m²)
- Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease, short bowel syndrome)
- Concurrent planned parathyroidectomy
- History of neck irradiation
- Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab, cinacalcet, chronic corticosteroids)
- Incomplete medical records lacking essential data including surgical details, postoperative calcium levels, or follow-up data
- Patients lost to follow-up before 6-month endpoint without documented outcome status
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Review of medical records for eligibility and data completeness
Surgery
Duration - Hospital stay of 2 to 5 days
Participants undergo thyroidectomy surgery as part of their clinical care.
Hospitalization for surgery and immediate postoperative monitoring
Post-operative Follow-up
Duration - Up to 6 months post-surgery
Participants have their calcium and parathyroid hormone levels monitored to assess for hypocalcemia and recovery.
Calcium and PTH level assessments at 24h, 48h, 1 week, 6 weeks, 3 months, and 6 months post-surgery; with additional visits as needed for supplementation and emergency care
Trial Site Locations
Total: 1 location
1
Minia University Hospital
Minya, Minya Governorate, Egypt, 61519
Actively Recruiting
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Research Team
S
Saleh K Saleh, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients.
Oliver Thomusch, Andreas Machens, Carsten Sekulla...
https://pubmed.ncbi.nlm.nih.gov/12605179Importance of in situ preservation of parathyroid glands during total thyroidectomy.
L Lorente-Poch, J J Sancho, S Ruiz...
https://pubmed.ncbi.nlm.nih.gov/25605285