A Pilot Study of Ozonated Oil Dressing to Reduce Early Wound Inflammation After Open Inguinal Hernia Surgery

What this Trial Is About

Researchers are evaluating whether a special wound dressing containing ozonated oil can reduce early wound inflammation after open inguinal hernia surgery. This surgery is common, and while infection rates are low, many patients experience redness, swelling, tenderness, or discomfort at the surgical site shortly after the operation. The study focuses on early wound inflammation rather than infection, aiming to gather preliminary data on the dressings effects compared to standard care. Participants undergoing elective open inguinal hernia repair will be randomly assigned to one of two groups one group will receive a sterile gauze dressing impregnated with CE-certified ozonated oil applied immediately after skin closure, with the dressing changed once daily for the first 48 hours, followed by standard wound care. The other group will receive a standard sterile dry dressing removed within 24 to 48 hours postoperatively, with subsequent wound care as per routine institutional practice. During the study, participants will be monitored for wound inflammation on the third day after surgery using a composite clinical and photographic score assessed by blinded evaluators. Additional measures include wound surface temperature, pain levels at several time points, cosmetic healing assessed on day 30, and wound-related complications within 30 days. The study aims to provide data on feasibility and effect size to guide future larger studies, with a total participation window covering the first 30 postoperative days.

Postoperative Ozonated Oil Dressing After Open Inguinal Hernia Repair: A Randomized Pilot Trial