Actively Recruiting
Postpartum Vaginal Estrogen for Breastfeeding Patients
Led by University Hospitals Cleveland Medical Center · Updated on 2026-03-10
100
Participants Needed
1
Research Sites
83 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sexual dysfunction is very common in the postpartum period and is more common in people who breastfeed or pump. This research study was designed to help determine whether postpartum patients who use vaginal estrogen cream while breastfeeding have improved sexual function compared to postpartum patients who do not.
CONDITIONS
Official Title
Postpartum Vaginal Estrogen for Breastfeeding Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Female and sexually active
- Singleton, term (37 weeks 0 days) birth
- Planning to breastfeed or pump during the study period
- History of successful breastfeeding or pumping after a prior pregnancy
- Between 6 weeks and 6 months postpartum (study starts at 6 weeks postpartum)
- Ability to consent in English
- Must not meet any exclusion criteria
You will not qualify if you...
- Preterm delivery
- Perinatal mortality
- History of difficulty breastfeeding
- 3rd or 4th degree perineal laceration
- Any contraindications to estrogen including breast cancer or history of breast cancer
- Estrogen-dependent neoplasia
- Active or history of deep vein thrombosis or pulmonary embolism
- Active or history of arterial thromboembolic disease (e.g., stroke, myocardial infarction)
- Known allergic reactions or hypersensitivity to estrogen
- Liver impairment or disease
- Protein C, protein S, or antithrombin deficiency or other thrombophilic disorders
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
S
Susan D Wherley, MD
CONTACT
R
Rosemary Brewka
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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