Postpartum Vaginal Estrogen for Sexual Function in Breastfeeding Patients: A Randomized Controlled Trial

What this Trial Is About

Researchers are studying sexual dysfunction in breastfeeding postpartum patients to see if using vaginal estrogen cream improves sexual function compared to not using it. This randomized clinical trial focuses on patients who have recently given birth and are breastfeeding or pumping, aiming to better understand treatment options during the postpartum period. Participants will be randomly assigned to one of two groups: one group will use estradiol vaginal inserts, and the other will use a vaginal moisturizer. Both treatments start after 6 weeks postpartum, with daily use for two weeks followed by twice-weekly use for ten weeks. Study supplies will be delivered to participants' homes, and instructions on usage will be provided. The study period lasts 12 weeks, with follow-up questionnaires at 6 weeks, 12 weeks, 6 months, and 1 year to assess long-term effects. Participants will complete questionnaires about sexual function, anxiety, depression, urinary symptoms, and vaginal health using secure online tools. Weekly messages will check breastfeeding status, sexual activity, vaginal pain, treatment use, and health changes. Safety monitoring will be conducted, and those showing signs of depression or anxiety will be referred for further care. The study measures sexual function scores up to 12 weeks and tracks participant wellbeing over one year.

Postpartum Vaginal Estrogen for Breastfeeding Patients