Actively Recruiting
Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency
Led by Université de Sherbrooke · Updated on 2026-02-10
16
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
Sponsors
U
Université de Sherbrooke
Lead Sponsor
I
Institut de Recherches Cliniques de Montreal
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on people with Lipoprotein Lipase Deficiency (LPLD), a condition where the enzyme lipoprotein lipase is lacking, causing very high levels of triglycerides in the blood. These patients often experience symptoms like abdominal pain and dizziness after meals and risk recurrent pancreatitis. The study aims to understand how LPLD affects the way dietary fatty acids are stored and used by organs, especially the heart, and how new treatments might influence this process. Participants will undergo three visits including a screening and two metabolic studies spaced 7 to 14 days apart. Each metabolic study lasts 9 hours and involves eating a low-fat liquid meal while researchers use PET scans and stable isotopic tracers to track fatty acid metabolism. The studies compare conditions with and without an intravenous heparin injection given before the meal. The groups include healthy controls and LPLD patients, each tested with and without heparin. During the study, participants will have detailed evaluations including heart function scans, blood tests, and metabolic assessments at specific intervals. Researchers will measure how dietary fatty acids are distributed to organs, used by the heart, and metabolized overall. The study also monitors insulin sensitivity, glucose turnover, and other metabolic markers over months. This comprehensive monitoring helps understand the disease impact and treatment effects over time.
CONDITIONS
Brief Title
Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Lipoprotein Lipase Deficiency (LPLD) subjects with a history of fasting triglycerides over 5 mmol/l and confirmed homozygote or compound heterozygote LPL-gene mutation
- Healthy control subjects with fasting glucose below 5.6 mmol/l, 2-hour post 75g OGTT glucose below 7.8 mmol/l, HbA1c below 5.8%, and fasting triglycerides below 1.5 mmol/l
- Willing and able to follow the study protocol
- Signed informed consent indicating understanding of the study purpose
You will not qualify if you...
- Age under 18 years
- Known cardiovascular disease as shown by medical history, physical exam, or abnormal ECG
- Treatment with fibrates, thiazolidinediones, beta-blockers, or other drugs affecting lipid or carbohydrate metabolism (except statins, metformin, and some antihypertensives that can be paused)
- Use of antihypertensive medication (only for LPLD individuals)
- Liver or kidney disease or uncontrolled thyroid disorder
- Previous diagnosis of heparin-induced thrombocytopenia
- Use of oral anticoagulants or platelet aggregation inhibitors
- History of major bleeding event
- Smoking more than 1 cigarette per day or drinking more than 2 alcoholic beverages daily
- Female participants who are pregnant, breastfeeding, planning pregnancy, or pre-menopausal with a positive pregnancy test at enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 to 4 weeks with 7 to 14 days between study visits
Participants undergo two metabolic study visits in random order, including ingestion of a low fat liquid meal with and without intravenous heparin. Each study lasts 9 hours involving metabolic measurements using PET and stable isotopic tracer methods.
2 visits (each lasting approximately 9 hours)
Trial Site Locations
Total: 1 location
1
Centre de recherche du CHUS
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
Research Team
F
Frédérique Frisch
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
Frequently Asked Questions
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