Actively Recruiting
A Randomized, Crossover, Controlled Trial Investigating the Effects of Different Cranberry-Based Beverages on Postprandial Glucose, Insulin, and GLP-1
Led by Ocean Spray Cranberries, Inc. · Updated on 2025-08-05
18
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
O
Ocean Spray Cranberries, Inc.
Lead Sponsor
B
Biofortis Innovation Services
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how different cranberry-based fruit juices affect blood sugar and insulin levels after eating. The study focuses on the immediate metabolic responses to these beverages, which may help clarify their role in diet and metabolic health. This trial is a randomized, controlled crossover design sponsored by Ocean Spray Cranberries, Inc., evaluating various fruit juice formulations in healthy adults. Participants will consume six different study beverages one at a time in a set order. Each visit involves drinking one type of fruit juice, followed by a 3 to 7-day break before the next beverage. The beverages include versions with zero sugar, low sugar (two formulations), full sugar (two formulations), and a glucose control drink. This crossover design allows each participant to experience all study products. During the study visits, participants will have blood samples taken to measure glucose, insulin, and GLP-1 hormone responses over 2 hours after consuming each beverage. Researchers will track blood sugar and insulin levels at multiple time points to assess changes and peak concentrations. The total participation period includes multiple visits spaced by wash-out periods, ensuring detailed monitoring of metabolic responses to the different juices.
CONDITIONS
Brief Title
Postprandial Response to Fruit Juice
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 45 years at first visit
- Body mass index (BMI) between 18.5 and less than 30 kg/m2 at first visit
- Fasting capillary glucose level at or below 110 mg/dL at first visit
- Willingness to avoid high-polyphenol foods for 48 hours before each test visit
- Willingness to abstain from alcohol for 24 hours before each study visit
- No use of tobacco or nicotine products within 12 months before first visit
- Non-habitual users of marijuana or hemp products and willing to abstain during the study
- Willing to maintain usual physical activity during the study
- Willing to maintain usual diet and stable intake of vitamins, minerals, supplements, and medications
- Score 7 to 10 on Vein Access Scale at first visit
- No health conditions preventing study participation as judged by the investigator
- Ability to understand study procedures and provide informed consent
You will not qualify if you...
- History or presence of serious cardiac, renal, liver, endocrine, lung, biliary, pancreatic, gastrointestinal, or neurological disorders affecting study participation or results
- Uncontrolled high blood pressure (systolic ≥140 mm Hg or diastolic ≥90 mm Hg) at first visit
- Recent unstable use (within 30 days) of blood pressure or thyroid hormone medications
- Use of medications or supplements affecting carbohydrate metabolism within 30 days of first visit
- Extreme dietary habits such as ketogenic, very high protein, high fiber, vegan, or vegetarian diets
- Weight change over 4.5 kg in 60 days before first visit
- Current or planned weight loss regimen during the study
- Use of weight loss medication within 90 days of first visit
- History of weight-reducing gastrointestinal surgery
- History of eating disorders diagnosed by a health professional
- Known allergy or sensitivity to ingredients in study beverages
- History of cancer in past 2 years except non-melanoma skin cancer
- Major trauma or surgery within 60 days before first visit
- Blood donation over 450 mL within 60 days before second visit or plans to donate during study
- Pregnancy, planning pregnancy, lactation, or unstable use of sex hormones for contraception
- Recent or potential alcohol or substance abuse
- Exposure to non-registered drug products within 30 days before first visit
- Any condition affecting consent, compliance, or study safety as judged by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 to 12 weeks depending on wash-out periods
Participants consume each of the 6 different cranberry-based beverages sequentially in a randomized crossover design, with a wash-out period between each product.
6 visits with 3-7 day wash-out periods between each visit
Trial Site Locations
Total: 1 location
1
Biofortis Innovation Services
Addison, Illinois, United States, 60101
Actively Recruiting
Research Team
K
Kristen S Smith, PhD, RD
C
Christina Khoo, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
6
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