Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults.
Austin T Robinson, Braxton A Linder, Alex M Barnett...
https://pubmed.ncbi.nlm.nih.gov/37619651Actively Recruiting
Phase Not Applicable
Age: 18Years - 30Years
All Genders
Healthy Volunteers
ID06062017
The Effects of Water and Potassium Supplementation on Cardiovascular and Kidney Function in Young Adults
Led by Auburn University · Updated on 2025-02-27
40
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
A
Auburn University
Lead Sponsor
I
Indiana University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how water with added potassium may improve hydration and cardiovascular health in young Black and White adults aged 18 to 30. This study focuses on addressing racial differences in hydration, blood pressure, and kidney function, given that Non-Hispanic Black adults face higher risks of cardiovascular disease and chronic kidney disease. The study also examines how socioeconomic factors affect hydration habits and health outcomes. Participants will undergo a 14-day hydration intervention where they will consume bottled water with or without a potassium supplement (2000 mg per day). Before this, there is a two-week period of habitual water and potassium consumption monitoring. The potassium supplement is provided as capsules containing potassium chloride powder. The study groups include 40 adults, equally divided by race and gender. During the study, researchers will measure blood pressure, arterial stiffness, and various biomarkers in urine and blood samples before and after the intervention. Assessments include urine specific gravity, urine osmolality, plasma copeptin levels, 24-hour ambulatory blood pressure, pulse wave velocity, and kidney blood velocity. The study also tracks sleep quality and dietary intake. Participants will be monitored throughout, with the entire process spanning about five weeks including the run-in and intervention periods.
CONDITIONS
Brief Title
Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)
Who Can Participate
Age: 18Years - 30Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Between the ages of 18-30 years
- Resting blood pressure no higher than 150/90 mmHg
- Body mass index (BMI) below 35 kg/m2
- Free of metabolic diseases such as diabetes, kidney disease, lung disorders, cardiovascular disease, autoimmune diseases, and no history of cancer
You will not qualify if you...
- Have medical conditions or medications that prevent blood donation, such as hemophilia or blood thinners like Pradaxa or Eliquis
- Currently pregnant or trying to become pregnant
- Taking medications that interact with potassium supplements, including RAAS blockers, certain non-steroidal anti-inflammatory drugs, non-selective beta-blockers, calcineurin inhibitors, or heparin and other blood thinners
- Any other precluding medical conditions as specified by the study team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Habitual Run-in Period
Duration - 2 weeks
Participants continue their usual water and potassium consumption while baseline measurements are collected.
Visits as needed for baseline assessments
Treatment
Duration - 2 weeks
Participants drink at least an extra 1L of water per day and take 2000 mg of potassium supplementation daily to improve hydration and cardiovascular health.
Visits to monitor adherence and collect health measurements
Follow-up
Duration - Duration of assessments immediately following treatment
Participants are monitored for changes in hydration, cardiovascular, and kidney function after the intervention.
Visits to assess treatment effects after supplementation period
Trial Site Locations
Total: 1 location
1
Kinesiology Building
Auburn, Alabama, United States, 36849
Actively Recruiting
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Research Team
N
Nina L Stute, M.S.
M
Meral A Culver, M.S.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
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Published Research Related To This Trial
Racial disparities in sleep health between Black and White young adults: The role of neighborhood safety in childhood.
Thomas E Fuller-Rowell, Olivia I Nichols, Austin T Robinson...
https://pubmed.ncbi.nlm.nih.gov/33798979Racial/Ethnic and Socioeconomic Disparities in Hydration Status Among US Adults and the Role of Tap Water and Other Beverage Intake.
Carolyn J Brooks, Steven L Gortmaker, Michael W Long...
https://pubmed.ncbi.nlm.nih.gov/28727528The relationship of perceptions of tap water safety with intake of sugar-sweetened beverages and plain water among US adults.
Stephen J Onufrak, Sohyun Park, Joseph R Sharkey...
https://pubmed.ncbi.nlm.nih.gov/23098620Perceptions of tap water and school water fountains and association with intake of plain water and sugar-sweetened beverages.
Stephen J Onufrak, Sohyun Park, Joseph R Sharkey...
https://pubmed.ncbi.nlm.nih.gov/24443781Perceptions of Water Safety and Tap Water Taste and Their Associations With Beverage Intake Among U.S. Adults.
Sohyun Park, Stephen J Onufrak, Angie L Cradock...
https://pubmed.ncbi.nlm.nih.gov/36609168