Actively Recruiting
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Led by University of Florida · Updated on 2026-05-01
45
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.
CONDITIONS
Official Title
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals fluent in English
- Have used opioids (e.g., oxycodone) at least once in their lifetime
- Are within 20% of their ideal body weight
- Are not currently experiencing chronic pain (pain on most days during the past 3 months)
- Have systolic blood pressure <=140, diastolic blood pressure <=90, and heart rate <=90 beats per minute
- Have normal electrocardiogram (EKG) and bloodwork showing no major health issues
You will not qualify if you...
- Significant current physical disease or major uncontrolled psychiatric disorder
- Currently interested in drug abuse treatment
- Women who are pregnant or nursing
- Severe comorbid illicit substance use disorders or clinically significant withdrawal for any abused drug except nicotine and caffeine
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
Research Team
L
Lauren E Nieder, MSPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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