Actively Recruiting
Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis
Led by IRCCS SYNLAB SDN · Updated on 2025-03-11
3
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
Sponsors
I
IRCCS SYNLAB SDN
Lead Sponsor
F
Federico II University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.
CONDITIONS
Official Title
Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex
- Patients without atherosclerosis undergoing surgical procedure for endocarditis
- Patients who will have signed informed consent
You will not qualify if you...
- Patients for whom biological material cannot be recovered for study purposes
- Patients who refuse to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Irccs Synlab Sdn
Naples, Italy, 80143
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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