Actively Recruiting
POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
Led by University of Copenhagen · Updated on 2025-06-13
30
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
Sponsors
U
University of Copenhagen
Lead Sponsor
R
Rigshospitalet, Denmark
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.
CONDITIONS
Official Title
POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 50 years
- Waist circumference less than 180 cm
- For POTS patients: diagnosed by tilt test or active stand test with reproducible orthostatic intolerance and heart rate increase (over 30 bpm for age above 19, over 40 bpm for age 18-19)
- POTS symptoms or orthostatic intolerance for POTS group
- For healthy participants: matched by age, sex, and BMI to POTS patients
You will not qualify if you...
- Chronic illness
- Metallic implants
- More than 10 alcoholic drinks per week or substance abuse
- Other types of sinus tachycardia or heart disease (for POTS group)
- Liver enzymes elevated to twice above normal
- Reduced kidney function (eGFR less than 90) or elevated creatine kinase
- Thyroid disease or abnormal TSH levels
- Uncontrolled low or high blood pressure
- Orthostatic hypotension (for healthy group)
- Blood vessels that cannot be visualized on MR scans
- Any disease or medications that cannot be paused for 36 hours and might affect health during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
Research Team
S
Sophie W Nielsen, MD
CONTACT
L
Lærke S Gasbjerg, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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