Predicting Extubation Success Using Peripheral Perfusion Index in ICU Patients Undergoing Mechanical Ventilation Weaning

What this Trial Is About

Researchers are studying the role of the Peripheral Perfusion Index PPI in predicting extubation success during the process of weaning patients off mechanical ventilation in the intensive care unit ICU. This observational study will compare PPIs predictive ability with traditional weaning criteria such as the Rapid Shallow Breathing Index RSBI, PaO2FiO2 ratio, and respiratory rate to better understand its usefulness in forecasting extubation failure. The study will be conducted in an ICU setting where patients who have been on mechanical ventilation for at least 48 hours and are ready for extubation after a spontaneous breathing trial SBT will be observed. Readiness for weaning will be assessed by a single intensivist using local protocols, including oxygenation, respiratory and cardiovascular stability, and other clinical criteria. Patients will undergo a 30-minute SBT with specific ventilation settings before extubation decisions are made. After extubation, patients will be monitored for 48 hours for any need for reintubation, with supplemental oxygen provided as needed. Participants will be monitored closely throughout the study, with PPI measured at multiple time points including the beginning, 15 minutes, and end of the SBT, as well as 1 and 2 hours after extubation. Researchers will evaluate PPIs ability to predict extubation failure within 48 hours as the primary outcome. Secondary outcomes include PPIs predictive power at other time points and its correlation with cardiac conditions. Data collection involves clinical assessments, respiratory measurements, and monitoring for reintubation over 48 hours post-extubation.

PPI in Weaning Prediction