Actively Recruiting
Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)
Led by Abramson Cancer Center at Penn Medicine · Updated on 2025-10-03
150
Participants Needed
3
Research Sites
65 weeks
Total Duration
On this page
Sponsors
A
Abramson Cancer Center at Penn Medicine
Lead Sponsor
B
Bristol-Myers Squibb
Collaborating Sponsor
AI-Summary
What this Trial Is About
The use of a geriatric assessment to inform oncologic care for older persons with cancer is an evidence-based practice that improves patient-clinician communication, reduces treatment-related toxicity, and is recommended by national guidelines. However, the implementation of a geriatric assessment can be time-consuming and burdensome, leading to suboptimal use in clinical practice. Developed and endorsed by the American Society for Clinical Oncology (ASCO), the Practical Geriatric Assessment (PGA) is designed to improve clinical usability and adoption, but its implementation in real-world settings has not been evaluated. The PACE-70 study aims to evaluate PGA implementation and resultant chemotherapy dose modification among older adults with advanced cancer treated in a community setting. An exploratory aim will evaluate how the PGA, body composition (via abdominal computed tomography scan) and step count monitoring (via FitBit) correlate with chemotherapy toxicity and other clinical outcomes.
CONDITIONS
Official Title
Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 70 years or older
- Diagnosis of advanced or metastatic solid malignancy
- Starting a new palliative-intent systemic therapy with a high risk of grade 3 toxicity
- For correlative analysis: able to read and speak English and complete surveys
- For correlative analysis: able to walk independently or with an assistive device
- For correlative analysis: consent to participate in Fitbit monitoring, body composition analysis, and surveys
- For correlative analysis: have a smartphone compatible with Fitbit
You will not qualify if you...
- For correlative analysis: unable to read and speak English
- For correlative analysis: reliance on a wheelchair, ECOG performance status of 3 or higher, clinically bedbound, or unable to walk without assistance daily in the past 7 days
- For correlative analysis: currently enrolled in a therapeutic clinical trial
- For correlative analysis: lack of clinician consent to approach the patient
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Penn Medicine Princeton Medical Center
Princeton, New Jersey, United States, 08540
Actively Recruiting
2
Lancaster General Hospital
Lancaster, Pennsylvania, United States, 17602
Not Yet Recruiting
3
Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
Research Team
A
Abigail Gottschalk, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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