Observational Study of Congestion Profiles in Adults With Acute Heart Failure Using Intravenous Diuretics

What this Trial Is About

Researchers are studying acute heart failure, focusing on different types of congestion in patients admitted with this condition. The study aims to understand how common these congestion types are and how they relate to patients responses to treatment and their health outcomes. This observational, prospective study involves patients who need intravenous loop diuretics and examines various effects of congestion on heart failure progression and recovery. Participants will have several additional assessments beyond usual care. These include ultrasound measures of filling pressures, lung and kidney investigations, liver stiffness tests using Fibroscan, and specialized imaging of the small blood vessels under the tongue. Some participants will join substudies involving skin biopsies to study tissue properties and evaluation of blood proteins related to venous congestion and endothelial function. During the hospital stay, researchers will monitor congestion types from admission until discharge, which typically occurs within 5 to 10 days. They will measure urine sodium output after 24 hours and track rehospitalization or death over six months. Other outcomes include hospital stay length, congestion status at discharge, and changes in heart filling pressures. Participants will undergo multiple scans and tests, and data on therapy response and long-term outcomes will be collected to better understand acute heart failure management.

a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure