Actively Recruiting
a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure
Led by University Medical Center Groningen · Updated on 2025-09-10
270
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients. The main question\[s\] it aims to answer \[is/are\]: * Primary objective: to study the prevalence of distinct congestion phenotypes * Other objectives (including): * Response to therapy as assessed by * Natriuresis after 24 hours * Rehospitalization and/or deats after 6 months * Length of hospital stay * Congestion at discharge * Changes in filling pressures over time * Relationship between liver stiffness, as assessed with Fibroscan and congestion * Substudy: glycosaminoglycan netword and endothial glycocalyx Participants will undergo several extra study related measurements: * Assessment of filling pressures with ultrasound * Ultrasound investigation of the lungs and kidneys * Fibroscan of the liver * Sidestream darkfield imaging sublingual * As part of substudy GLYCO-AHF: skin biopsy to determine glycocalyx, as well as salt and water content. * As part of substudy PREACH-AHF: the effects of peripheral venous congestion and endothelial dysfunction on a large screen of plasma proteins
CONDITIONS
Official Title
a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able and willing to give written informed consent
- Age 65 18 years
- Male or female
- Primary diagnosis of acute heart failure at presentation, with signs and symptoms of tissue decongestion based on ESC HF guidelines
- Requirement of intravenous loop diuretics
You will not qualify if you...
- Severe kidney dysfunction requiring ultrafiltration or dialysis
- Previous participation in this study
- Inability to follow instructions
- Breathing problems or swelling primarily caused by non-cardiac reasons
AI-Screening
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Trial Site Locations
Total: 1 location
1
UMCG
Groningen, Netherlands
Actively Recruiting
Research Team
J
Jozine M. ter Maaten, MD, PhD
CONTACT
L
Lara E.E.C. Zonneveld, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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