Actively Recruiting
A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
Led by Holly Ende · Updated on 2025-10-01
10000
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
H
Holly Ende
Lead Sponsor
V
Vanderbilt University Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research project aims to enhance the safety of childbirth by using advanced computer models to predict the risk of postpartum hemorrhage (PPH). PPH is a significant concern for mothers during and after delivery. Current risk assessment tools are basic and do not adapt to changing conditions. This study will investigate whether a new and recently validated model for predicting PPH, combined with a provider-facing Best Practice Advisory (BPA) regarding currently recommended strategies triggered by an increased predicted risk, can improve perinatal outcomes. This study will compare the current category based risk assessment tool with a new, enhanced prediction model which calculates risk based on 21 factors, automatically updates as new information becomes available during labor and, if elevated, provides a provider-facing Best Practice Advisory (BPA) recommending consideration of strategies that are institutionally agreed to represent high-quality practice. Investigators hypothesize that the enhanced care approach will result in improved perinatal outcomes. The goal of the study is to improve the wellbeing of mothers during childbirth by harnessing the power of modern technology and data analysis.
CONDITIONS
Official Title
A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All vaginal and cesarean deliveries occurring at Vanderbilt University Medical Center
You will not qualify if you...
- Patients discharged before delivery are excluded from analysis
- Patients with a planned pre-delivery hysterectomy for placenta increta or percreta are excluded from the treatment algorithm and primary analysis
AI-Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
Research Team
H
Holly Ende, MD
CONTACT
T
Tracie Baker, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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