Actively Recruiting
A Pragmatic Rehabilitation Intervention: The Active Rehab Study
Led by University of North Carolina, Chapel Hill · Updated on 2026-02-27
130
Participants Needed
2
Research Sites
117 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
The strategic objective of this research line is to examine improving short- and long-term outcomes for soldiers following mild traumatic brain injury (mTBI). The technical objectives are to: 1) conduct a Phase 1 quasi-experimental pragmatic trial testing the potential benefit of provider directed active rehabilitation therapies ("Active Rehab") in accelerating return of injured soldiers back to active duty and improving cognitive and functional limitations following mTBI, and 2) operationalize and disseminate a clinical active rehabilitation algorithm for use in military settings. The central hypothesis is that an active rehabilitation algorithm in the context of the progressive return to activity will improve clinical and functional outcomes, including time to return to duty. The Active Rehab intervention expands on progressive return to activity guidelines by providing activities that can be completed and progressed during Stage 1 of the progressive return to activity protocol, when the participant is at least 24 hours postinjury. Active Rehab includes an adaptive paradigm based on personal characteristics, symptom presentation, and duty requirements that integrate with current progressive return to activity guidelines. Activity progressions consider the initial presentation and changes in participant status during treatment, with the goal of safely accelerating recovery. Severity and presence of symptoms will guide progression: worse, same or better as reported by the participant.
CONDITIONS
Official Title
A Pragmatic Rehabilitation Intervention: The Active Rehab Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current active duty military personnel stationed at Fort Bragg, North Carolina
- Available for recruitment within 2 weeks of mild traumatic brain injury (mTBI) injury date
- Initial provider diagnosis of mTBI/concussion within 2 weeks of injury, confirmed by medical record
You will not qualify if you...
- Three or more mTBI/concussions in the past 12 months
- Symptoms resolved at rest and exertion within 48 hours
- Moderate to severe traumatic brain injury or TBI not meeting mild criteria
- Other injuries preventing completion of initial assessments within 2 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
United States Special Operations Command
Fort Liberty, North Carolina, United States, 28310
Actively Recruiting
2
Womack Army Medical Center
Fort Liberty, North Carolina, United States, 28310
Actively Recruiting
Research Team
J
Johna K Register-Mihalik, PhD
CONTACT
P
Paula Gildner, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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