Actively Recruiting
A Pragmatic Trial of Machine Prescription for Migraine
Led by Norwegian University of Science and Technology · Updated on 2025-03-25
200
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to estimate the ability of ML models to predict the effect of migraine preventives. This will be achieved by first identifying sociodemographic, headache and comorbidity features of migraine patients. Headache days will then be measured for 4 weeks before starting a migraine preventive, and this will be compared to the number of headache days in the first 12 weeks (divided into 28-day periods) after starting treatment. The preventive is regarded as effective if there is a 50% or greater reduction in monthly headache days. After observation of the treatment period, the ML models will use the sociodemographic, headache and comorbidity features, captured before treatment was initiated, to predict treatment effect for all preventives in each participant. These predicted treatment effects will be compared to the actual treatment effects that were observed.
CONDITIONS
Official Title
A Pragmatic Trial of Machine Prescription for Migraine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older at trial entry
- Diagnosed with episodic or chronic migraine with or without aura according to ICHD-3 criteria
- Migraine onset before age 50 years
- History of at least 4 migraine days in the 4-week baseline period based on headache diaries or recall
- Recently started or planning to start a migraine preventive within the last 4 weeks
- Signed and dated informed consent
You will not qualify if you...
- Currently using a migraine preventive medication that is not part of the study
- Previously failed all six migraine preventive treatments being researched
- Diagnosed with trigeminal autonomic cephalalgias or facial neuralgias
- Having secondary headache conditions, except medication overuse headache
- Taking opioids more than 3 days per month or barbiturates at screening
- Alcohol overuse or illicit drug use
- Participating in another clinical investigation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NTNU Norwegian University of Science and Technology
Trondheim, Norway, 7030
Actively Recruiting
Research Team
A
Anker Stubberud, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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