Actively Recruiting
Pragmatic Trial of Obsessive-compulsive Disorder
Led by Shanghai Mental Health Center · Updated on 2025-05-15
1600
Participants Needed
1
Research Sites
431 weeks
Total Duration
On this page
Sponsors
S
Shanghai Mental Health Center
Lead Sponsor
T
The first specialized hospital of harbin
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study includes a sequenced clinical trial in order to assess the efficacy of several switching or augment strategies when initial treatment is ineffective，and to provide strong evidence for clinical practice and international guidelines for Obsessive-Compulsive Disorder treatments.
CONDITIONS
Official Title
Pragmatic Trial of Obsessive-compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet DSM-5 diagnostic criteria for OCD as the primary diagnosis
- Age between 18 and 65 years
- Score at least 20 on Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)
- Have never received medication for OCD
- Have not received any psychotherapy for OCD in the past 1 month
- Provided written informed consent
You will not qualify if you...
- Diagnosed with Schizophrenia Spectrum or other psychotic disorders, or Bipolar and related disorders
- Have moderate or higher suicide risk (≥9 on MINI Suicide Module)
- Severe substance use in the past year that may affect treatment adherence
- Severe depression with Beck Depression Inventory (BDI) score of 29 or higher
- Comorbid psychiatric or medical disorders affecting medication adherence or efficacy (e.g., borderline personality disorder, CNS disorders)
- Pregnant or lactating females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
Z
Zhen Wang, PhD,MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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