Actively Recruiting
Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein
Led by Texas A&M University · Updated on 2025-11-25
100
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.
CONDITIONS
Official Title
Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 to 95 years old
- Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) for COPD group only
- Stable body weight within ±5% for the past 3 months
- Ability to walk, sit down, and stand up independently or with a walking assistance device
- Willingness to lie supine in bed for up to 6 hours
- Willingness and ability to comply with the study protocol
You will not qualify if you...
- Diagnosis and active treatment of insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, moderate to severe asthma, or hepatitis A, B, or C
- History of untreated metabolic disease including liver or kidney disorder
- Presence of acute illness or metabolically unstable chronic illness
- History of hysterectomy
- Active dependence on alcohol or drugs
- Use of short-term oral corticosteroids within 4 weeks before study day
- Current use of long-term oral corticosteroids
- Use of protein or amino acid nutritional supplements within 5 days before the first study day
- Fever within the last 3 days
- Planned elective surgery requiring 2 or more days of hospitalization during the study
- Possible pregnancy
- Inability or unwillingness to give informed consent
- Enrollment in another clinical trial
- Any condition found during screening that may interfere with study or patient safety
- Known allergy to soy, pea, or whey (dairy) proteins
- Established daily vegetarian or vegan diet
- Montreal Cognitive Assessment (MoCa) score below 23
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Texas A&M University - CTRAL
College Station, Texas, United States, 77845
Actively Recruiting
Research Team
M
Marielle Engelen, PhD
CONTACT
S
Savanah Knezek, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
8
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