Whole-body and intracellular arginine metabolism in hypertension: role of disease severity and sex.
V N Hüttl, Nep Deutz, R A Wierzchowska-McNew...
https://pubmed.ncbi.nlm.nih.gov/42149813Actively Recruiting
Phase Not Applicable
Age: 50Years - 95Years
All Genders
Healthy Volunteers
ID06628349
Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein
Led by Texas A&M University · Updated on 2025-11-25
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how different types of protein, specifically plant-based versus animal-based proteins, affect muscle-building responses in older adults, including those with sarcopenia and chronic obstructive pulmonary disease (COPD). The study aims to understand how essential and non-essential amino acids influence these responses to help develop better nutritional strategies to prevent and treat muscle loss in aging populations. Participants will consume one of four liquid nutritional supplements during study visits: whey protein (animal-based), soy protein (plant-based), pea protein (plant-based), or a placebo of water. These supplements are given as sip feeds every 20 minutes over a 5-hour period. The study includes a screening visit and four study days, with participants having the option to add sugar-free vanilla, caramel, or chocolate syrup to their drinks. Participants will visit the research center fasting, undergo body composition and muscle function tests, and provide blood samples before and after feeding to measure protein and amino acid synthesis using stable isotope tracers. Vital signs and physical performance tests like the Six-Minute Walk Test are conducted. The study tracks metabolic responses and muscle function over about four weeks, with all data securely stored for analysis.
CONDITIONS
Brief Title
Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein
Who Can Participate
Age: 50Years - 95Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 50 to 95 years old
- Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) for COPD group participants only
- Stable body weight within plus or minus 5% for the past 3 months
- Ability to walk, sit down, and stand up independently or with a walking assistance device
- Willingness to lie flat in bed for up to 6 hours
- Willingness and ability to follow the study protocol
You will not qualify if you...
- Active or treated chronic diseases including insulin dependent diabetes, active cancer, heart, kidney, liver disease, HIV/AIDS, moderate to severe asthma, or hepatitis A, B, or C
- Untreated metabolic diseases such as liver or kidney disorders
- Acute illness or unstable chronic illness
- History of hysterectomy
- Dependence on alcohol or drugs
- Use of oral corticosteroids within 4 weeks before the study or long-term corticosteroid use
- Use of protein or amino acid supplements within 5 days before the study
- Fever within the last 3 days
- Planned surgery requiring hospitalization for 2 or more days during the study
- Pregnancy or possible pregnancy
- Inability or unwillingness to provide informed consent
- Participation in another clinical trial
- Any condition that might interfere with the study or safety as judged by the investigator or nurse
- Known allergies to soy, pea, or whey protein
- Vegetarian or vegan diet
- Montreal Cognitive Assessment (MoCA) score below 23
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) lasting approximately 3 hours
Treatment
Duration - 4 study days
Participants receive different protein supplements or placebo in a randomized crossover design. Each treatment day involves sip feeding of a liquid nutritional supplement every 20 minutes for 5 hours with baseline and tracer blood sampling to assess metabolic responses.
4 visits (in-person), one for each supplement administration
Trial Site Locations
Total: 1 location
1
Texas A&M University - CTRAL
College Station, Texas, United States, 77845
Actively Recruiting
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Research Team
M
Marielle Engelen, PhD
S
Savanah Knezek, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
8
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