Actively Recruiting
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
Led by Singapore General Hospital · Updated on 2026-04-29
50
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
Sponsors
S
Singapore General Hospital
Lead Sponsor
S
Singapore Civil Defence Force
Collaborating Sponsor
AI-Summary
What this Trial Is About
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.
CONDITIONS
Official Title
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Out-of-hospital cardiac arrest attended by Singapore Civil Defence Force paramedics
- Return of spontaneous circulation achieved before hospital arrival
- Age 16 to 80 years
- Comatose after return of spontaneous circulation with Glasgow Coma Scale of 8 or less
You will not qualify if you...
- Older than 80 years
- Cardiac arrest caused by trauma
- Tympanic temperature below 34°C at assessment
- Pregnancy
- Resuscitation stopped in the Emergency Department
- Life support withdrawn within 24 hours of Coronary Care Unit admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National University Heart Centre, Singapore (NUHCS)
Singapore, Singapore, 119074
Actively Recruiting
Research Team
S
Shir Lynn Lim, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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