Actively Recruiting

Phase 4
Age: 50Years +
All Genders
NCT07217626

Pre-Incision Peripheral Nerve Blocks for Lower Extremity Fracture Surgery in Older Adults

Led by University of Maryland, Baltimore · Updated on 2026-03-30

34

Participants Needed

1

Research Sites

44 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Fractures of the lower leg are especially difficult for older adults. They are more likely to have serious complications, require longer healing times, and have a higher risk of death This occurs because their bodies cannot tolerate stress as well as younger individuals. The injury itself places significant strain on the body, and surgery adds additional stress. Anesthesiologists use nerve blocks to help manage pain during and after these injuries. A nerve block is an injection that numbs the fracture and surgery area by blocking pain signals. These injections help patients need fewer opioid medications. However, new research shows these nerve blocks may provide benefits beyond pain management. Studies looking at older adults with hip fractures who received nerve blocks showed better overall outcomes: fewer deaths, fewer serious complications, and shorter hospital stays. However, it is not currently known if nerve blocks work this well for other broken bones in the leg, like in the thigh or shin. Additional research is need to know if nerve blocks can help patients with all types of leg fractures recover faster and experience fewer problems. Before the investigators start a large clinical trial, a small pilot study needs to be completed to determine if a larger clinical trial is feasible. This pilot study will evaluate the ability to recruit enough patients, ensure patients can receive the assigned treatment, collect data effectively, follow the study protocol, and track participants over time. The results will indicate whether the investigators are prepared to proceed with a full-scale trial and help refine the approach.

CONDITIONS

Official Title

Pre-Incision Peripheral Nerve Blocks for Lower Extremity Fracture Surgery in Older Adults

Who Can Participate

Age: 50Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 50 years or older
  • Have isolated lower extremity fractures confirmed by X-ray or imaging
  • Fracture types include femoral shaft, distal femur, patella, proximal tibia, tibial shaft, distal tibia, pilon, ankle (malleolar), calcaneus, talus, or hindfoot/midfoot
  • Fracture must be acute and receiving surgical fixation during the current injury hospitalization
  • Ability to provide informed consent personally or via a legally authorized representative
Not Eligible

You will not qualify if you...

  • Contraindications to peripheral nerve block, such as infection at the injection site, patient refusal, or medical refusal by surgeon or anesthesiologist
  • Active peripheral nerve block from initial injury pain management with risk of local anesthetic toxicity
  • Neurologic or vascular injuries in the affected limb
  • Polytrauma including traumatic brain injury
  • Thoracic or abdominal injuries requiring surgery
  • Current participation in another conflicting clinical trial
  • Living in an acute or subacute care facility prior to injury
  • Incarcerated at enrollment
  • Prior enrollment in this trial
  • Unable to give informed consent due to language barriers or lack of legal representative
  • Expected difficulty complying with follow-up requirements

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Maryland

Baltimore, Maryland, United States, 21201

Actively Recruiting

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Research Team

A

Arissa Torrie, MD, MHS

CONTACT

H

Heather Phipps, MPS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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