Comparing Pre-Surgery Injections of Ropivacaine With or Without Diprospan to Reduce Pain After Laparoscopic Surgery in Adults

What this Trial Is About

Laparoscopic surgery often causes significant postoperative pain due to inflammation around the incision site, affecting up to 80% of patients. This research evaluates whether adding diprospan, a corticosteroid with anti-inflammatory properties, to ropivacaine for preemptive incisional infiltration can better relieve pain after laparoscopic surgery compared to ropivacaine alone. The trial also examines patient safety and quality of recovery. Participants receive pre-incisional infiltration before surgery, with one group receiving a combination of diprospan and ropivacaine, while the other group receives ropivacaine alone. The infiltration is performed layer by layer according to the surgeons incision markings. The study uses a randomized, parallel design with quadruple masking to compare the two treatments. During the study, researchers monitor pain relief using opioid consumption within 48 hours after surgery as the primary measure. Secondary assessments include pain scores at rest and during movement over 72 hours, patient satisfaction, nausea, vomiting, wound healing, scar evaluation, and adverse events. Participants are followed up to 3 months postoperatively to assess outcomes and recovery quality.

Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery