Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07060261

Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma

Led by Case Comprehensive Cancer Center · Updated on 2026-05-05

30

Participants Needed

1

Research Sites

39 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This prospective research study aims to see if pre-operative MRI can predict the margin status after transoral robotic surgery (TORS) for human papillomavirus positive (HPV+) tonsillar squamous cell carcinoma (SCC). The pre-operative MRI will have a standard MR neck without and with contrast, with added axial T2 weighted sequence and T2 SPACE sequence through the tonsils. Three neuroradiologists will grade the thickness of the pharyngeal constrictor muscle (the muscle that surrounds the tonsils) on a five-point scale. The study will determine if the pre-operative MRI grading will correlate with positive, insecure (\<1mm), or secure (\>1mm) margin during TORS surgery for your HPV+ tonsillar SCC.

CONDITIONS

Official Title

Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults  18 years of age
  • Being considered for transoral robotic surgery (TORS) for HPV positive tonsillar squamous cell carcinoma
Not Eligible

You will not qualify if you...

  • Younger than 18 years of age
  • Unable to provide informed consent
  • Do not wish to participate
  • Vulnerable populations including cognitively impaired persons, pregnant women, and students or house staff under investigator supervision
  • Contraindication to MRI

AI-Screening

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Trial Site Locations

Total: 1 location

1

Case Comprehensive Cancer Center, Cleveland Clinic Foundation

Cleveland, Ohio, United States, 44195

Actively Recruiting

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Research Team

J

Jonathan Lee, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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