Actively Recruiting
Pre-operative Hypofractionated Proton Therapy
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2026-04-17
40
Participants Needed
1
Research Sites
449 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
R
Robert L. Sloan Fund for Cancer Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to examine whether proton therapy for certain kinds of sarcomas (extremity and trunk soft tissue) is safe and effective. As part of the study, patients will have five fractions of proton therapy before the participants have surgery for the sarcoma. The study will measure wound complications and functional outcomes / quality of life after the procedures. Patients will be asked to complete questionnaires about the treatment and quality of life from the time of enrollment until about two years after surgery. Otherwise, the participants will have standard of care follow ups with the treatment team.
CONDITIONS
Official Title
Pre-operative Hypofractionated Proton Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (18 years of age or older)
- Patients with primary or locally recurrent extremity or truncal soft tissue sarcoma
- WHO/ECOG status 2 or better
You will not qualify if you...
- History of prior local radiation therapy
- Inability to tolerate treatment position for duration of simulation or treatment
- Tumor originating in retroperitoneal location
- Patients planned for systemic therapy including chemotherapy, targeted agents, and immunotherapy
- Co-existing malignancy or treated malignancy in the last 2 years expected to limit life expectancy; exceptions include completely resected cutaneous basal cell carcinoma, squamous cell carcinoma, in situ breast or cervical malignancies, or other pathologies at the discretion of investigators
- Confirmed pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
Research Team
C
Curtiland Deville, MD
CONTACT
R
Ryan Manuel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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