Actively Recruiting
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
Led by University Hospital, Geneva · Updated on 2026-05-08
91
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass. The primary objective of this study is to evaluate whether preoperative fat-free mass predicts weight loss in the two years following RYGB. The investigators will collect the following data, assessed as part of routine follow-up: * height, weight, hip and waist circumferences * body composition by bioimpedance analysis and dual energy-X-ray absorptiometry * Muscle strength and physical activity * Nutritional parameters: resting energy expenditure, eating behavior and digestive tolerance", plasma micronutrient status. . * Cardiovascular risk factors: fasting glucose, blood levels of Hb1Ac, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, blood pressure * Co-morbidities: joint pain and arthritis, sleep apnea, gastro-oesophageal reflux, metabolic dysfunction-associated fatty liver disease (MAFLD), cancer, stroke, heart attack. Quality of life: quality of life by the "Bariatric Analysis and Reporting Outcome (BAROS) questionnaire", symptoms of dumping syndrome by the "Sigstad diagnostic score system" Birthdate, birthweight and term of their children
CONDITIONS
Official Title
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Eligible for Roux-En-Y gastric bypass with BMI 35 kg/m2 or higher
- Failed weight loss programs for 2 years (or 1 year if BMI 50 or higher)
- Understand the need to change lifestyle and eating habits after surgery
- Signed consent for lifelong follow-up at a recognized bariatric center
- Scheduled for RYGB at HUG or had previous RYGB at HUG with current follow-up
- Understand French
You will not qualify if you...
- Unable or unwilling to give consent
- Planning a type of bariatric surgery other than Roux-En-Y gastric bypass
- Contraindications to bariatric surgery including insufficient nutritional knowledge
- Pregnancy
- Kidney failure with creatinine 300 umol/l or higher without dialysis
- Crohn's disease
- Active cancer or cancer remission less than 2 years
- Active psychiatric disease
- Substance abuse (alcohol, cannabis, opioids)
- Non-compliance or lack of understanding of required lifestyle changes as reported by physician or dietician
AI-Screening
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Trial Site Locations
Total: 1 location
1
Geneva University Hospitals
Geneva, Canton of Geneva, Switzerland, 1205
Actively Recruiting
Research Team
L
Laurence Genton, MD
CONTACT
L
Laure Wilmart-Beck
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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