Differential contributions of bilateral ventral anterior temporal lobe and left anterior superior temporal gyrus to semantic processes.
M Visser, M A Lambon Ralph
https://pubmed.ncbi.nlm.nih.gov/21391767Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID05339438
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in Drug-resistant Epileptic Patients
Led by Central Hospital, Nancy, France · Updated on 2025-07-01
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying drug-resistant anterior temporal lobe epilepsy, a common type of focal epilepsy where seizures persist despite medication. This epilepsy affects important brain areas involved in naming, understanding meaning, and recognizing faces. Surgery to remove the affected temporal lobe area can stop seizures but may cause cognitive problems. This study aims to better map brain functions in the ventral anterior temporal lobe (vATL) to predict and reduce post-surgery cognitive issues. The study uses advanced brain imaging techniques during functional MRI (fMRI) scans. These include a new Multi-Band sequence and a special way of showing visual stimuli called Fast Periodic Visual Stimulation (FPVS). These methods improve the detection of brain activity in the vATL, which is often hard to see clearly with standard MRI. Both epilepsy patients scheduled for surgery and healthy volunteers will undergo about 1.5 hours of fMRI scanning using these innovative approaches. Participants will be evaluated through the functional MRI scans to measure brain activity in the anterior temporal lobe over three years. The scans focus on areas involved in naming, semantic processing, and face recognition. The study does not affect surgical decisions yet but hopes to improve future surgery planning to protect cognitive functions. Participants will give informed consent and be monitored for safety during the scans. The overall goal is to enhance understanding of brain function to improve outcomes for epilepsy surgery patients.
CONDITIONS
Brief Title
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adult person
- Person affiliated to a social security scheme or beneficiary of such a scheme
- Person having received complete information on the organization of the Clinical Investigation and having signed informed consent
- Person having carried out a preliminary clinical examination adapted to the Clinical Investigation
- For patients: Person with drug-resistant structural focal epilepsy of the anterior temporal lobe (right or left), candidate for epilepsy surgery (anterior temporal lobectomy)
- For healthy volunteers: Person with no known pathology in the anterior temporal lobe (particularly epilepsy)
You will not qualify if you...
- Contraindication to MRI including claustrophobia
- Uncorrected visual disturbances
- Person unable to give consent
- Lack of mastery of the French language or ability to understand instructions
- Person referred to in Articles 64, 65 and 66 of European Regulation 2017/745: Person of full age unable to consent alone to participate in the Clinical Investigation; Minor; Pregnant or breastfeeding woman
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo functional MRI scanning to map the anterior temporal lobe activity using innovative techniques.
1 visit (approximately 1.5 hours, in-person)
Long-term Monitoring
Duration - 3 years
Participants are monitored for functional anterior temporal lobe activity over 3 years.
Follow-up visits as scheduled for monitoring
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Régional Universitaire de Nancy
Nancy, France
Actively Recruiting
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Research Team
J
Jacques JONAS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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Alexander M Puckett, Saskia Bollmann, Benedikt A Poser...
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https://pubmed.ncbi.nlm.nih.gov/29502144