Actively Recruiting
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases
Led by M.D. Anderson Cancer Center · Updated on 2025-09-05
180
Participants Needed
1
Research Sites
429 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase III trial studies stereotactic radiosurgery (SRS) before surgery to see how well it works compared with SRS after surgery in treating patients with cancer that has spread to the brain (brain metastases). SRS is the delivery of focused, high-dose radiation given in a single session to the tumors, with a minimal dose given to uninvolved areas of the brain.
CONDITIONS
Official Title
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The primary brain lesion before surgery can be up to 4 cm for single fraction SRS or up to 7 cm for multifraction therapy
- Patients must be candidates for stereotactic radiosurgery within 30 days before or after surgical removal of brain tumors
- Patients must have a Karnofsky performance score of 70 or higher or an ECOG score of 2 or less within 30 days before enrollment
- Patients must agree to randomization and sign informed consent
- No signs of leptomeningeal disease on brain imaging reviewed by specialists
- Must have a documented history of cancer
You will not qualify if you...
- Patients who have had prior radiation therapy to the brain
- Patients with primary tumors that are small-cell lung cancer, lymphoma, leukemia, or multiple myeloma
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
D
Debra Yeboa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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