Actively Recruiting
Pre-Sleep Creatine Monohydrate Supplementation to Enhance Anaerobic Power in Recreationally Active Females
Led by Ankara Yildirim Beyazıt University · Updated on 2025-04-22
24
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how taking creatine monohydrate before sleep affects anaerobic performance and muscle damage in recreationally active females aged 18 to 25. This randomized, placebo-controlled trial aims to understand if short-term, time-specific creatine supplementation can improve power output and reduce muscle damage markers during exercise. The focus is on evaluating effects through performance tests and blood markers related to muscle recovery. Participants will be randomly assigned to one of two groups: one receiving 5 grams of creatine monohydrate powder dissolved in flavored water, and the other receiving a visually identical placebo powder made of maltodextrin. Both supplements are taken 30 minutes before sleep each night for seven consecutive days. The trial compares the impact of creatine versus placebo on anaerobic power and muscle damage. During the study, participants will undergo the Wingate Anaerobic Test at the start and end of the supplementation period to measure average and peak power output as well as fatigue index. Blood samples will be collected before and after the intervention to assess muscle damage markers such as creatine kinase and lactate dehydrogenase. The study includes careful tracking of diet and training routines, with total participation lasting just over one week.
CONDITIONS
Brief Title
Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, aged 18 to 25 years
- Recreationally active with structured resistance training 3-4 times per week for the past 6 months
- Regular menstrual cycles
- Able and willing to provide informed consent
- Agree to maintain normal diet and training routines throughout the study
You will not qualify if you...
- History of musculoskeletal injury affecting lower or upper limbs within the past 6 months
- Known allergy or intolerance to creatine or maltodextrin
- Use of performance-enhancing substances or supplements within the last 30 days
- Use of recovery methods such as massage, cryotherapy, or compression garments during the study
- Current use of anti-inflammatory medication
- Pregnancy or breastfeeding
- Inability to comply with study protocol or scheduled assessments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 days
Participants take 5 grams of creatine monohydrate or a placebo dissolved in water, 30 minutes before sleep each night for 7 days.
2 visits (baseline and post-intervention assessments)
Trial Site Locations
Total: 1 location
1
Islamic Azad University, Shabestar Branch
Shabestar, East Azerbaijan Province, Iran, 5381637183
Actively Recruiting
Research Team
M
Morteza Jourkesh, PhD
C
Caglar Soylu, phD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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