Study of Mulberry Fruit Juice Effects on Gut Health and Atopic Dermatitis in Children and Teens Randomized Trial Comparing Mulberry Juice Plus Standard Treatment to Standard Care Alone

What this Trial Is About

This research aims to explore the potential prebiotic effects of mulberry fruit juice on children and adolescents with atopic dermatitis. It will investigate how consuming mulberry juice might influence the severity of the skin condition, gut microbiota, and metabolites. The study will enroll up to 120 participants aged 6 to under 18 years, focusing on those diagnosed with atopic dermatitis for more than six months. The project is supported by Taipei Medical University Hospital and commissioned by the Ministry of Health and Welfare. Participants will be randomly assigned to either a control group receiving standard atopic dermatitis treatment, including Mometasone furoate 0.1% cream, or an experimental group receiving the same standard therapy plus 200 ml of mulberry fruit juice daily. The intervention lasts three months, with five clinical assessments and three stool collections scheduled during this period. The study will compare changes in atopic dermatitis severity, gut microbiota composition, and metabolites between the two groups. During the study, participants will undergo regular evaluations including clinical assessments of skin condition and quality of life. Stool samples will be collected to analyze changes in gut bacteria and metabolic products. Researchers will measure changes in metabolism starting from six days after beginning juice intake and track atopic dermatitis severity and life quality over the full 12 weeks. The study includes monitoring for safety and adherence, with total participation lasting three months.

Prebiotic Effects of Mulberry Fruit in Children and Adolescents With Atopic Dermatitis