Actively Recruiting
Prebiotic Treatment in People With Schizophrenia
Led by University of Maryland, Baltimore · Updated on 2026-03-09
60
Participants Needed
1
Research Sites
205 weeks
Total Duration
On this page
Sponsors
U
University of Maryland, Baltimore
Lead Sponsor
N
National Center for Complementary and Integrative Health (NCCIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed project is based on the observation that schizophrenia is characterized by a chronic pro-inflammatory state, which contributes to the severity of a number of the clinical manifestations of the illness, including cognitive impairments, the treatment of which represents a critically important unmet therapeutic need.
CONDITIONS
Official Title
Prebiotic Treatment in People With Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- DSM-5 diagnosis of schizophrenia or schizoaffective disorder
- Age 18 to 60 years
- Considered clinically stable by the treating psychiatrist
- Currently treated with an antipsychotic with no dose changes in last 14 days
- Ability to participate in informed consent process with a score of 10 or greater on the Evaluation to Sign Consent
- Body mass index (BMI) less than or equal to 40
You will not qualify if you...
- Gastrointestinal disorders that could affect schizophrenia treatment or increase risk, including Crohn's disease, irritable bowel syndrome, celiac disease
- Organic brain disorders such as stroke, epilepsy, traumatic brain injury, or loss of consciousness over 30 minutes
- Intellectual disability
- Recent acute antibiotic use
- Immune therapy within the last three months
- Prebiotic or probiotic treatment within the last three months
- Inability to understand English
- Inability to cooperate with study procedures
- Pregnant or lactating due to pregnancy
- Alcohol or substance misuse (except caffeine and nicotine) within the last 3 months; mild marijuana misuse allowed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Maryland Psyciatric Research Center
Catonsville, Maryland, United States, 21228
Actively Recruiting
Research Team
M
Matt Glassman
CONTACT
J
Jennifer Zaranski, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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