Actively Recruiting
Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes
Led by German Institute of Human Nutrition · Updated on 2025-09-12
30
Participants Needed
1
Research Sites
127 weeks
Total Duration
On this page
Sponsors
G
German Institute of Human Nutrition
Lead Sponsor
T
Technische Universität Dresden
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with overweight and with normal, or impaired glucose metabolism (prediabetes and type 2 diabetes). In addition, the study aims to elucidate the molecular mechanisms underlying these effects.
CONDITIONS
Official Title
Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Overweight or obesity (BMI 25-40 kg/m²)
- Healthy glucose metabolism with fasting glucose below 100 mg/dl and glucose after 2 hours OGTT below 140 mg/dl
- OR impaired glucose metabolism with fasting glucose between 100-125 mg/dl and/or glucose after 2 hours OGTT 140-199 mg/dl and/or HbA1c between 5.7-6.4%
- OR type 2 diabetes diagnosed medically or with fasting glucose above 126 mg/dl and/or glucose after 2 hours OGTT above 200 mg/dl and/or HbA1c 6.5% or higher
- Daily eating window of 12 hours or more
You will not qualify if you...
- Weight changes greater than 5% within the past 3 months
- Shift work
- Traveling across more than one time zone within one month before the study
- Pregnancy and breastfeeding
- Eating disorders, food intolerance or allergy to diet product ingredients, vegan diet, or currently practicing time-restricted eating
- Severe chronic illnesses or conditions incompatible with the intervention (e.g., type 1 diabetes, recent cardiovascular event, malabsorption, cancer in last two years)
- Treatment with insulin, sulfonylureas, GLP-1 receptor agonists, steroid use, regular melatonin intake, or anticoagulation treatments that cannot be paused
- Extreme early or late chronotypes
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
German Institute of Human Nutrition Potsdam-Rehbruecke
Nuthetal, Germany, 14558
Actively Recruiting
Research Team
O
Olga Ramich, Prof. Dr.
CONTACT
B
Bettina Schuppelius, M.Sc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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