Actively Recruiting
Precise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of Schizophrenia
Led by Shanghai Mental Health Center · Updated on 2025-03-26
81
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Based on the current background and our previous studies, TUS has been proved that rTUS intervention could induce long-term potentiation like (LTP-like) plasticity and neuromodulate the brain cortex in schizophrenia patients. rTUS over the left dorsolateral prefrontal cortex (DLPFC) can alleviate the negative symptoms in schizophrenia. In this double-blind, randomized, sham-controlled study, the efficacy of different treatment options and mechanisms of low-intensity rTUS on negative symptoms will be investigated.
CONDITIONS
Official Title
Precise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the DSM-5 diagnostic criteria for schizophrenia or schizoaffective disorder
- Age 18 to 50 years old, right-handed, Han nationality
- Score of at least 4 (moderate or above) on at least one PANSS negative symptom item (N1 to N7)
- Stable condition with at least 4 weeks of treatment using second-generation antipsychotics
- Provided written informed consent
You will not qualify if you...
- Current or past neurological illness, severe physical diseases, substance abuse or alcohol dependence, mental retardation, pregnancy or lactation
- Uncooperative or high-risk patients with severe excitement, stupor, disordered behavior, or suicidal tendencies
- History of modified electroconvulsive therapy (MECT) or other physical therapy within 6 months
- History of epilepsy or epileptic waves on baseline EEG
- Use of antiepileptic drugs or high doses of benzodiazepines beyond specified limits
- Contraindications to transcranial ultrasound stimulation (TUS) or MRI
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
D
Dengtang LIU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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