Actively Recruiting
Precision Antibiotic Dosing for Appendectomy
Led by University of Michigan · Updated on 2026-03-06
46
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
A
Agency for Healthcare Research and Quality (AHRQ)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research is studying a drug called cefoxitin already approved by the Food and Drug Administration (FDA) to reduce the risk of infection after surgery to remove an appendix. Researchers are studying a large group of people to continue to learn how best to dose antibiotics. This research will compare the current standard treatment which is a single dose prior to surgery to a new method that includes adding another dose of cefoxitin within 30 minutes of starting the surgery. This study will measure cefoxitin concentrations in blood, fat, and appendix tissue samples to compare the standard dosing method to our new method. This information will help us figure out the right dose of this drug to prevent infection after surgery to remove an appendix.
CONDITIONS
Official Title
Precision Antibiotic Dosing for Appendectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acute appendicitis and plan to undergo appendectomy at the University of Michigan
- Age 18 years or older
You will not qualify if you...
- Prisoners
- Pregnant individuals
- Patients with perforation or abscess on CT scan
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Michigan Medicine
Ann Arbor, Michigan, United States, 48108
Actively Recruiting
Research Team
A
Alexsas Matvekas, BS
CONTACT
J
June Sullivan, MBA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here