Study on Patient Decisions and Preferences for Preventive Tuberculosis Treatment Using a Discrete Choice Experiment

What this Trial Is About

Researchers are studying tuberculosis TB prevention by exploring how people decide to start preventive treatment after being tested for latent TB infection LTBI. This study is part of a larger program aiming to develop and test new ways to identify who will benefit most from preventive treatment. The main goals are to understand patient decision-making about starting preventive treatment and to evaluate preferences through a special survey called a discrete choice experiment. The study has two stages. In the first stage, up to 30 adults undergoing routine LTBI testing will participate in interviews to share their experiences and thoughts about preventive treatment. In the second stage, about 200 patients and 200 healthcare workers will complete a survey designed to measure how they weigh the risks of TB against their willingness to accept preventive treatment. This survey helps researchers understand the factors influencing treatment decisions from both patient and provider viewpoints. Participants will be involved through interviews or surveys based on their role and testing status. The study will collect information on preventive treatment acceptance as the main outcome. Participants will be adults tested for LTBI or eligible for testing, including migrants from high TB incidence countries, recent TB contacts, or those undergoing screening before certain medical treatments. The study will continue until December 2026 and is sponsored by University College London.

PRecision biomArker-Guided MAnagement of TuberculosIs Contacts: a Discrete Choice Experiment