Actively Recruiting
Precision Dosing of Metformin in Youth With T2D
Led by University of California, San Francisco · Updated on 2025-12-23
20
Participants Needed
2
Research Sites
140 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
CONDITIONS
Official Title
Precision Dosing of Metformin in Youth With T2D
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 10 to 21 years
- Diagnosis of Type 2 Diabetes by a healthcare provider
- Stable medication regimen for at least 2 weeks before screening with no medication additions/removals and less than 20% change in insulin dose
- At least 1 month since Type 2 Diabetes diagnosis
- Currently taking regular (non-extended-release) metformin
- Ability to wear a continuous glucose monitor (CGM) for 6 weeks during the study
- Able to speak English or Spanish
- Willing to follow study recommendations and procedures
- Willing and able to sign informed consent (or have a parent/guardian who can)
- Participant and parent/guardian willing to participate in all training sessions and comply with study requirements
You will not qualify if you...
- Positive test for pancreatic autoantibodies (GAD-65, insulin, IA-2, ICA 512, Zn-T8)
- Known ongoing kidney or liver disease
- Significant mental illness or developmental delay that prevents completing study activities independently
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic
Oakland, California, United States, 94609
Actively Recruiting
2
UCSF Benioff Children's Hospital San Francisco, Madison Clinic for Pediatric Diabetes
San Francisco, California, United States, 94158
Actively Recruiting
Research Team
A
Avani A Narayan, MS
CONTACT
L
Laura A. Dapkus Humphries, NCPT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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