Actively Recruiting
Precision Exercise to Improve Outcomes in Sepsis
Led by University of British Columbia · Updated on 2024-12-18
32
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
Sponsors
U
University of British Columbia
Lead Sponsor
V
Vancouver Coastal Health Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this interventional clinical research study is to assess the efficacy of a 12-week precision exercise training intervention to improve exercise tolerance in sepsis survivors. The main question it aims to answer is does a 12-week precision exercise training program improve constant load exercise time in sepsis survivors? Participants will: * Answer questionnaires related to patient reported outcomes and give a blood sample * Perform a constant load exercise test * Complete 12-weeks (3 x per week, 36 session in total) of precision exercise training consisting of individualized, nonlinear periodized strength and aerobic exercise training. Researchers will compare the exercise group to an attention control group of sepsis survivors who do not receive exercise training but instead undergo usual care procedures and receive general lifestyle advice 1x per week.
CONDITIONS
Official Title
Precision Exercise to Improve Outcomes in Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- At least 19 years of age
- At least 60 days prior to enrollment, known or suspected infection with at least two quickSOFA criteria: respiratory rate >22 breaths/min, altered mentation, or systolic blood pressure <100 mmHg
- Cardiorespiratory fitness below 80% of age and sex-predicted norms
- Ability to attend 3 exercise sessions per week for 12 weeks
You will not qualify if you...
- Unable to provide informed consent
- Currently on supplemental oxygen
- Known previous cardiac or cerebral vascular events in the past 90 days
- Diabetes
- Autoimmune diseases or on daily immunomodulatory drugs
- Obstructive sleep apnea
- Uncontrolled hypertension
- Known pregnancy, intending to become pregnant within 28 days of enrollment, or breastfeeding
- Oxygen saturation below 85% during exercise
- Cardiovascular contraindications or musculoskeletal limitations to exercise as assessed during testing
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
St. Paul's Hospital - Centre for Heart Lung Innovation
Vancouver, British Columbia, Canada
Actively Recruiting
Research Team
G
Graeme Koelwyn, PhD
CONTACT
J
John Boyd, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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