Personalized Precision Geromedicine Program Combining Lifestyle, Supplements, and Exercise to Improve Health in Adults Aged 50 to 80

What this Trial Is About

This research aims to evaluate a personalized precision geromedicine approach designed to improve key aging hallmarks and promote healthy aging in adults aged 50 to 80 years. The study focuses on middle-aged to older individuals who have lower than average cardiorespiratory fitness and cognitive performance, targeting early declines in muscle, immune, and cognitive functions to enhance overall healthspan and delay functional deterioration. Participants will undergo an 8-week multimodal intervention that includes lifestyle changes, dietary supplements, and supervised exercise with an exergaming component. Two groups receive either a fundamental lifestyle intervention with nutritional supplements or an augmented intervention with additional personalized supplements based on baseline muscle mass, fitness, and cognitive assessments, with possible adjustments mid-study. Throughout the study, participants will attend regular assessments to track changes in fitness, muscle strength and mass, cognitive function, immune markers, and other biological and clinical indicators. These evaluations occur at baseline, week 4, and week 8, involving physical tests, imaging, cognitive batteries, and blood analyses. The study also monitors adherence, quality of life, and well-being during the intervention period.

PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)