Actively Recruiting
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
Led by National University of Singapore · Updated on 2026-03-05
20
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
X
Xprize Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .
CONDITIONS
Official Title
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50-80 years (both male and female)
- Relatively healthy and in stable health condition
- Not engaged in regular resistance or aerobic training in the past 12 months (untrained)
- VO2peak below the 75th percentile for age- and sex-specific norms
- Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery
- Willing and able to comply with exercise and supplementation protocols
- English-literate (can read and understand English)
- Provides written informed consent
- Deemed to have mental capacity as assessed by the Principal Investigator
- Able to attend all research visits for screening and data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore
You will not qualify if you...
- Significant change in medication in the past 3 months
- History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
- More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
- Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
- Participation in another interventional clinical trial
- Current use of any study-related supplement unless willing to stop
- Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance
- Pregnant or planning pregnancy during the study period
- Any conditions deemed by PI that jeopardize safety or study compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore 117597
Singapore, Singapore, Singapore, 117597
Actively Recruiting
Research Team
A
Ajla Hodzic Kuerec, MD, PhD
CONTACT
M
Mazzarine Dotou, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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