Actively Recruiting
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
Led by National University of Singapore · Updated on 2026-03-05
20
Participants Needed
1
Research Sites
18 weeks
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
X
Xprize Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate a personalized precision geromedicine approach designed to improve key aging hallmarks and promote healthy aging in adults aged 50 to 80 years. The study focuses on middle-aged to older individuals who have lower than average cardiorespiratory fitness and cognitive performance, targeting early declines in muscle, immune, and cognitive functions to enhance overall healthspan and delay functional deterioration. Participants will undergo an 8-week multimodal intervention that includes lifestyle changes, dietary supplements, and supervised exercise with an exergaming component. Two groups receive either a fundamental lifestyle intervention with nutritional supplements or an augmented intervention with additional personalized supplements based on baseline muscle mass, fitness, and cognitive assessments, with possible adjustments mid-study. Throughout the study, participants will attend regular assessments to track changes in fitness, muscle strength and mass, cognitive function, immune markers, and other biological and clinical indicators. These evaluations occur at baseline, week 4, and week 8, involving physical tests, imaging, cognitive batteries, and blood analyses. The study also monitors adherence, quality of life, and well-being during the intervention period.
CONDITIONS
Brief Title
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50-80 years, male or female
- Generally healthy and stable health condition
- Not regularly engaged in resistance or aerobic training in past 12 months
- Cardiorespiratory fitness (VO2peak) below 75th percentile for age and sex
- Cognitive performance below 75th percentile on NIH Toolbox Cognitive Battery
- Willing and able to follow exercise and supplementation protocols
- Able to read and understand English
- Provides written informed consent
- Assessed to have mental capacity by Principal Investigator
- Able to attend all research visits at study site
You will not qualify if you...
- Significant medication changes in past 3 months
- History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
- More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
- Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
- Participation in another interventional clinical trial
- Current use of study supplements unless willing to stop
- Medical, psychiatric, or cognitive conditions that risk safety or compliance
- Pregnant or planning pregnancy during study period
- Any condition deemed by Principal Investigator to pose safety or compliance risks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants undergo an 8-week personalized intervention combining lifestyle modifications, supervised exercise with cognitive tasks and exergaming, motivational interviewing, and tailored nutritional supplementation based on individual assessments.
Weekly visits during the 8-week intervention and 2 motivational interviewing sessions
Trial Site Locations
Total: 1 location
1
MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore 117597
Singapore, Singapore, Singapore, 117597
Actively Recruiting
Research Team
A
Ajla Hodzic Kuerec, MD, PhD
M
Mazzarine Dotou, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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