Evaluating Skin Patch and Breath Analyzer Devices for Early Detection and Follow-Up of Melanoma Metastases in Adults

What this Trial Is About

Researchers are evaluating the use of minimally and non-invasive technologies, such as a skin patch and a breath analyzer, to detect volatile organic compounds VOCs for the early identification of melanoma metastases. This prospective observational study also aims to assess how usable these devices are in monitoring high-risk melanoma patients. The study compares these methods with standard imaging techniques and liquid biopsy biomarkers for metastatic melanoma detection. Participants will undergo testing with two devices a breath analyzer, where they will breathe into the device after sitting quietly for at least 10 minutes, and a skin patch placed on the arm for about an hour to collect skin VOCs. Additionally, blood samples will be collected for liquid biopsy to analyze tumor DNA mutations. The study will track patients with both non-metastatic and metastatic melanoma over a 24-month period. During the study, researchers will collect and analyze VOC profiles and genetic data, comparing them to current standard diagnostic and prognostic tools. Participants will be monitored regularly throughout the 24 months to assess early metastasis detection and follow-up of high-risk melanoma. The study involves non-invasive procedures and standard clinical assessments to evaluate device effectiveness and usability.

Precision Medicine for L/GCMN and Melanoma 2