Actively Recruiting
Precision Medicine: MRI-Guided Stereotactic Ablative Radiotherapy (MRI-SABR) for Early-Stage Glottic Laryngeal Cancer
Led by Viktoras Rudzianskas · Updated on 2026-02-05
105
Participants Needed
1
Research Sites
495 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized phase III trial will compare the outcomes of three treatment modalities for early-stage glottic laryngeal cancer (T1-T2N0): transoral CO₂ laser microsurgery (TLM), volumetric modulated arc therapy (VMAT), and MRI-guided stereotactic ablative radiotherapy (MRI-SABR). The primary endpoint is local control (LC). Secondary endpoints include laryngectomy-free survival (LFS), progression-free survival (PFS). overall survival (OS), functional voice, swallowing and breathing outcomes, treatment-related complications, and the evaluation of radiomic and dosiomic biomarkers. Patients will be randomized in a 1:1:1 ratio. Total planned enrollment is 105.
CONDITIONS
Official Title
Precision Medicine: MRI-Guided Stereotactic Ablative Radiotherapy (MRI-SABR) for Early-Stage Glottic Laryngeal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically confirmed squamous cell carcinoma of the glottic larynx, including verrucous carcinoma
- Stage T1-T2N0 according to the 8th TNM edition
- ECOG performance status of 0 to 2
- Able to understand Lithuanian and complete questionnaires
- Signed informed consent to participate
You will not qualify if you...
- AJCC stage III or IV laryngeal cancer
- Previous radiotherapy for head and neck cancer
- Pregnancy or breastfeeding
- Contraindications to radiotherapy or inability to attend follow-up visits
- Presence of another active cancer
- Uncontrolled illnesses such as active infection, symptomatic congestive heart failure, unstable angina, or significant arrhythmia
- Any other condition that would prevent radiotherapy or adequate follow-up as judged by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Lithuanian University of Health Sciences Kaunas Clinics
Kaunas, Lithuania
Actively Recruiting
Research Team
V
Viktoras Rudzianskas
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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