Actively Recruiting
Precision Medicine for Nociception, Sngception and Proprioception.
Led by National Taiwan University Hospital · Updated on 2024-10-21
160
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
Sponsors
N
National Taiwan University Hospital
Lead Sponsor
N
National Science and Technology Council
Collaborating Sponsor
AI-Summary
What this Trial Is About
Precision medicine is defined as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person" by the Precision Medicine Initiative. Patients have different response to different treatment modalities, and sore/pain medicine is no exception. In our experience, low-level laser (LLL), ultrasound, and prolotherapy can reduce sore /pain through different genetic pathway. Whether the therapeutic effect is controlled by the genetic variants of those sore /pain related genes or not, is still in debate. The aims of this study are (1) To set up next generation sequencing (NGS)-based approach to find genetic variants which can determine the response of sng/pain treatment modalities and the phenotype of idiopathic scoliosis. (2) To find possible metabolomics and proteomic markers of sng/pain. (3) To determine the algorithm of precision medicine for sng/pain control via the genetic markers. Investigators will recruit 80 myofascial pain participant and 80 idiopathic scoliosis participant from Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Bei-Hu Branch in 2023 and 2025. The myofascial pain participant participants will receive LLL, ultrasound, and prolotherapy, and the therapeutic effect will be recorded. The clinical trial will evaluate the Sng / pain (VAS) and muscle tone of the idiopathic scoliosis participant. The blood and urine samples from the first, the second, and the third visits will be analyzed by next generation sequencing, and mass spectrometry to find the possible biomarker in 2024 and 2025. Investigators expect to develop the individualized treatment plan by means of these biomarkers. Hopefully, the results will be widely applied in the field of sore /pain medicine.
CONDITIONS
Official Title
Precision Medicine for Nociception, Sngception and Proprioception.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cohort A: Age between 20 and 100 years old
- Cohort A: Visual Analogue Scale (VAS) score of 30 or higher, or VAS score of 30 or higher at 4 kg pressure
- Cohort A: Diagnosed with myofascial pain syndrome and willing to receive LLLT, therapeutic ultrasound, or local dextrose injection therapy
- Cohort B: Age between 13 and 65 years old
- Cohort B: Diagnosed with idiopathic scoliosis confirmed by antero-posterior X-ray with Cobb angle greater than 10 degrees
You will not qualify if you...
- Cohort A: Active infection, malignancy, or hematological diseases
- Cohort A: Received local injection at upper trapezius within 6 months
- Cohort B: Active infection, malignancy, or hematological diseases
- Cohort B: Specific causes of scoliosis such as congenital, neuromuscular, syndromic, or degenerative scoliosis
- Cohort B: Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital Bei-Hu Branch
Taipei, Taiwan, 802
Actively Recruiting
Research Team
D
Der-Sheng Han, Physician
CONTACT
D
Der-Sheng Han, Physician
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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