Actively Recruiting
Precision Radiotherapy Enabled by Molecular MRI
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2026-05-06
20
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
T
The Ben & Catherine Ivy Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a research study to determine if a novel molecular magnetic resonance imaging (MRI) technique, called amide proton transfer (APT) imaging, is useful in identifying the most aggressive areas of tumor needed for radiotherapy of brain tumors.
CONDITIONS
Official Title
Precision Radiotherapy Enabled by Molecular MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologic confirmation of glioblastoma or grade 4 astrocytoma
- Age over 18 years
- Karnofsky Performance Status (KPS) of at least 60
- Normal organ and marrow function including leukocytes > 3,000/mcL, absolute neutrophil count > 1,500/mcL, platelets > 100,000/mcL
- Total bilirubin within normal institutional limits
- AST/ALT less than 2.5 times institutional upper limit of normal
- Creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 if creatinine elevated
- Patients of child-bearing potential must use adequate contraception
- Ability and willingness to sign informed consent
You will not qualify if you...
- Inability to receive MRI scans
- Receiving other investigational cancer treatments at enrollment
- Previous overlapping brain radiotherapy treatment
- Uncontrolled illness such as active infection, symptomatic heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social conditions limiting study compliance
- Pregnant or breastfeeding women
- Women of child-bearing potential unwilling or unable to use effective birth control during study and 12 weeks after
- Male subjects unwilling to use effective contraception during study and 12 weeks after
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
K
Kristin Redmond
CONTACT
R
Ryan Manuel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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