Actively Recruiting
Predicting Failure of Non-invasive Ventilatory Support Using Non-invasive Monitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure: the PREVISION Study
Led by Unity Health Toronto · Updated on 2025-05-20
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate non-invasive tools to identify risks of failure when using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV) in patients with acute hypoxemic respiratory failure or post-extubation failure. The main question is whether abnormal regional ventilation can predict failure of HFNC or NIV. This is a single-center, prospective observational study assessing physiological responses in non-intubated patients. Participants who are using HFNC or NIV to prevent worsening respiratory failure or reintubation will be monitored with electrical impedance tomography (EIT) and muscle ultrasound. EIT sensors placed around the chest will record ventilation distribution for 5-10 minutes without causing pain or discomfort. Muscle activity of the diaphragm and parasternal intercostal muscles will also be assessed during these therapies. Additional data including respiratory parameters, dyspnea scores, and hospital stay lengths will be collected. Each participant's monitoring session will last about 30 minutes and occurs once during the study. Researchers will follow patients for up to 7 days to determine failure of HFNC or NIV, defined as intubation, reintubation, or death. Data analysis will be done offline with dedicated software, and patient confidentiality will be maintained. The study collects both physiological measurements and clinical data from medical records to understand factors predicting ventilatory support failure.
CONDITIONS
Brief Title
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age of 218 years or older
- Currently using non-invasive ventilation (NIV) or high flow nasal cannula (HFNC) in the hospital
You will not qualify if you...
- Chronic carbon dioxide (CO2) retention
- Neuromuscular disorder
- Requiring home NIV (CPAP or BIPAP)
- Tracheostomy
- Contraindication to electrical impedance tomography (EIT) placement such as pacemaker, defibrillator, or burns at the chest area
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - About 30 minutes
Participants undergo non-invasive monitoring including electrical impedance tomography (EIT) and muscle ultrasound while using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV). Relevant respiratory and clinical parameters are recorded during this one-time assessment.
1 visit (in-person)
Duration - Up to 7 days
Participants are followed for up to 7 days to monitor outcomes such as treatment failure, including intubation, reintubation, or death, through chart review and clinical observation.
Follow-up via medical record review and clinical observation
Trial Site Locations
Total: 1 location
1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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