Actively Recruiting
Predicting Language Recovery in Acute Stroke Patients: An Exploratory Study Using the Core Assessment of Language Processing
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-06-04
570
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Stroke affects many people and often leads to lasting difficulties with movement and thinking. One serious problem is aphasia, which affects language skills and can be hard to recover from if not treated early. Researchers are studying whether tests done soon after a stroke, including a language test called the Core Assessment of Language Processing (CALAP), can predict how well patients will recover their language abilities later on. This study includes patients hospitalized within 21 days of a stroke affecting one side of the brain. Participants will undergo language and cognitive assessments, brain MRI scans, and neurological exams during their hospital stay and again between 3 and 18 months later. Researchers will use these data to build models predicting language and cognitive recovery and to see if early language tests combined with MRI and neuropsychological data improve prediction. They will also examine if language rehabilitation changes these predictions. Participants will be involved in two main visits for assessments including clinical exams, cognitive tests, and MRI scans. The study aims to follow about 570 stroke patients over 6 years. The main measure is how well the CALAP score predicts language recovery 18 months after stroke. Secondary measures include improving predictions using MRI, neuropsychological data, and rehab information. This research hopes to help guide better care and rehabilitation for stroke survivors with language difficulties.
CONDITIONS
Brief Title
Predicting Language Recovery in Acute Stroke Patients in the Neurovascular Intensive Care Unit: An Exploratory Study With the Core Assessment of Language Processing.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years old
- Hospitalized within 21 days after a hemispheric stroke (ischemic or hemorrhagic)
- Ability to participate in language and cognitive tests
- French-speaking
- NIHSS score between 4 and 21, or if less than 4, LAST score between 0 and 13
- No opposition to participation in tests
You will not qualify if you...
- Severe alertness impairment preventing test participation (NIHSS score 1a not equal to 0)
- Severe intellectual deterioration preventing test participation
- Visual or hearing impairments incompatible with CALAP participation
- History of previous stroke
- Stroke located in the posterior fossa
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 21 days after stroke
Participants undergo language and cognitive assessments including the Core Assessment of Language Processing and neuropsychological tests.
1 to 2 visits depending on assessments
Duration - 18 months
Participants are monitored for language and cognitive recovery over 18 months following the stroke.
Follow-up visits for assessments over 18 months
Trial Site Locations
Total: 1 location
1
Assistance Publique Hôpitaux de Paris - Hôpital Henri Mondor
Créteil, France, 94010
Actively Recruiting
Research Team
A
Anne-Catherine BACHOUD-LEVI, MD, PhD
T
Tiffany MONNIER, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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