Actively Recruiting
Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion
Led by Peking University Third Hospital · Updated on 2023-02-21
232
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations, as well as a accurate and systematic pathological grading standard of inferior vena cava (IVC) vascular wall invasion in renal cell carcinoma (RCC) with tumor thrombus invading vascular wall.The main questions it aims to answer are: * To establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations. * To determine what impact does different vascular wall layer invasion make on the long-term prognosis in RCC with IVC tumor thrombus; * To determine which layer invasion according to pathological examination make sense to clinical treatment (can significantly affect prognosis); Participants with IVC vascular wall invasion/ non-invasion are divided into experimental group (invaded group) or control group (non-invaded group) respectively according to pathological examinations, in order to establish a prospective cohort with three-year follow-up. The pathological characteristics of local recurrence and poor prognosis are summarized, and postoperative pathological diagnostic criteria of IVC vascular wall invasion and established. The local recurrence and distant recurrence outcomes are compared between experiment group and control group, in order to analyze the long-term influence of vascular wall invasion. Then the preoperative imaging diagnostic evaluation model will be established.
CONDITIONS
Official Title
Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 6518 years of age
- Had abdominal ultrasonography, contrast-induced ultrasonography, enhanced CT, and MRI before surgery
- Diagnosed with primary renal cell carcinoma with tumor thrombus before and during surgery
- Received radical nephrectomy and at least one type of thrombectomy (including IVC incision only, IVC partial resection, IVC diagonal resection, or IVC segmental resection)
- Able to tolerate surgery
- Eastern Cooperative Oncology Group Performance Status Scale (ECOG-PS) 0 to 2
- No previous history of malignant tumor
- Willing to attend required follow-up visits
You will not qualify if you...
- Did not receive standard nephrectomy for any reason
- Had additional operations during surgery
- Received neoadjuvant treatment before surgery
- Have conditions that may affect treatment outcome (such as active tuberculosis, autoimmune disease, or oral glucocorticoid treatment)
- Experienced serious consequences or death due to anesthesia accident during operation
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
Research Team
J
Jiyuan Chen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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