Actively Recruiting
Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
Led by Shanghai Chest Hospital · Updated on 2025-05-18
200
Participants Needed
1
Research Sites
211 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single center, prospective and observational study conducted in three stages to predict the NSCLC lymph node metastasis based on ctDNA/specific methylation molecular features combined with PET-CT imaging features and intervention study.
CONDITIONS
Official Title
Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provision of informed consent prior to study initiation.
- Age between 18 and 75 years.
- Preoperative clinical evaluation indicating non-small cell lung cancer (NSCLC) stage I-IIIB.
- Newly treated patients who consent to undergo surgery.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1.
You will not qualify if you...
- NSCLC determined to be other than stage I-IIIB after surgery.
- Presence of other active malignant tumors.
- Serious or uncontrolled systemic illness including uncontrolled hypertension and active bleeding.
- Active infectious diseases such as hepatitis B, hepatitis C, or HIV infection.
- History or evidence of interstitial lung disease, drug-induced ILD, or radiation pneumonitis requiring steroid therapy.
- Patients unable to comply with the study protocol or with conditions impeding participation as judged by the investigator.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Chest Hospital
Shanghai, China
Actively Recruiting
Research Team
F
Feng Yao, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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