Actively Recruiting
Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
Led by Fred Hutchinson Cancer Center · Updated on 2025-11-19
300
Participants Needed
10
Research Sites
317 weeks
Total Duration
On this page
Sponsors
F
Fred Hutchinson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Collecting and analyzing clinical data and blood samples from patients with cGVHD before and after treatment initiation may help doctors identify changes that may predict treatment response.
CONDITIONS
Official Title
Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults age 18 or older
- Prior allogeneic stem cell transplant with any graft source, donor type, and GVHD prophylaxis
- No evidence of persistent or progressive malignancy at enrollment
- Willing to be evaluated at the transplant center before starting a new treatment and at 2-6 weeks, 3 months, and 6 months after treatment start or if a new therapy is added before 6 months
- Signed informed consent
You will not qualify if you...
- Unable to comply with study procedures
- Uncontrolled psychiatric disorder
- Expected survival less than 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
University of Florida
Gainesville, Florida, United States, 32610
Completed
2
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
3
Dana-Farber Harvard Cancer Center
Boston, Massachusetts, United States, 02115
Actively Recruiting
4
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Completed
5
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Completed
6
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
7
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Completed
8
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37232
Completed
9
Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, United States, 98109
Actively Recruiting
10
Vancouver General Hospital/BC Cancer
Vancouver, British Columbia, Canada, V5Z 4E6
Completed
Research Team
G
Gaby Desatnik
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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