Actively Recruiting
Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack
Led by Guy's and St Thomas' NHS Foundation Trust · Updated on 2024-09-25
90
Participants Needed
2
Research Sites
257 weeks
Total Duration
On this page
Sponsors
G
Guy's and St Thomas' NHS Foundation Trust
Lead Sponsor
K
King's College London
Collaborating Sponsor
AI-Summary
What this Trial Is About
Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time. Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecessary risk. On the other hand, narrowings that are currently left alone because they appear mild, may progress and cause a heart attack. Participants who have had a heart attack will have a scan from inside the heart arteries during an angiogram (optical coherence tomography, OCT) and a magnetic resonance angiogram (MRA). If the investigators can show that it is possible to accurately predict which non-culprit narrowings are going to progress and which are going to stabilise, medical professionals may be able to better target their treatments after a heart attack.
CONDITIONS
Official Title
Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Successful primary percutaneous coronary intervention (PCI) within the previous week with no major complications at the index procedure
- Bystander disease in a non-culprit vessel planned for clinically indicated staged angiography +/- PCI
- Able to provide written informed consent.
You will not qualify if you...
- Cardiogenic shock requiring intubation, inotropes or a mechanical support device
- Creatinine clearance less than 30 ml/min
- Prior coronary artery bypass grafting
- Life expectancy less than 3 years
- Pregnancy
- Target lesion in the left main coronary artery
- Severe calcification or tortuosity that would threaten safe placement of a pressure wire or OCT catheter
- Chronic total occlusion of a major epicardial vessel.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
St Thomas' Hospital
London, United Kingdom, SE1 7EH
Actively Recruiting
2
King's College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
Research Team
M
Matthew Li Kam Wa, MBBS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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