Actively Recruiting
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
Led by Xijing Hospital of Digestive Diseases · Updated on 2025-07-24
150
Participants Needed
3
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients. The main questions it aims to answer are: * Investigating the alterations in brain functional connectivity in patients with refractory constipation and fluoxetine-sensitive patients * Assessing the predictive value of brain functional connectivity regarding the efficacy of fluoxetine and standard protocol treatments for constipation. Participants will receive: * Standard physiological and psychological assessments of constipation * BOLD-fMRI tests * Standard protocol and fluoxetine treatment If there is a comparison group: Researchers will compare: Refractory group/Fluoxetine sensitive group to see the specific brain alterations.
CONDITIONS
Official Title
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years old
- Right-handed
- Diagnosed with functional constipation according to Rome IV criteria
- Provided informed consent
You will not qualify if you...
- Presence of gastrointestinal organic diseases or significant functional abnormalities (e.g., tuberculosis, polyps, Crohn's disease, tumors, congenital megacolon, pelvic floor muscle relaxation, abnormal colonic transit test)
- Engages in long-term intense exercise exceeding 8 hours per week
- No history of chronic pain or recent major trauma
- Drug abuse or tobacco dependence (half a pack or more per day)
- Has hypothyroidism or Parkinson's disease
- Confirmed mental illness or neurological disorders taking psychotropic drugs, analgesics, or hormones
- History of abdominal surgery such as appendectomy, hysterectomy, or cholecystectomy
- Contraindications to functional MRI (such as claustrophobia or metal implants)
- Pregnant or lactating women or constipation after delivery
- Patients with benign or malignant tumors and autoimmune diseases
- Infectious diseases including hepatitis B, hepatitis C, AIDS
- Heart disease, organ failure, or other chronic diseases requiring long-term medication or affecting quality of life
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
People's Hospital of Ningxia Hui Autonomous Region
Yinchuan, Ningxia, China, 750002
Actively Recruiting
2
Xi'an International Medical Center Hospital
Xi'an, Shaanxi, China, 710032
Actively Recruiting
3
Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032
Actively Recruiting
Research Team
Z
Zhifeng Zhao
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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