Using Metabolic Biomarkers to Predict One-Year Success of Vital Pulp Treatment in Teeth with Carious Pulp Exposure

What this Trial Is About

Researchers are investigating whether metabolic biomarkers found in pulpal blood at the time of carious pulp exposure can predict the success of vital pulp treatment in symptomatic permanent teeth over 12 months. This controlled clinical trial focuses on patients aged 16 to 50 years with deep carious pulp exposure, aiming to improve pulpal diagnosis and guide treatment decisions using measurable biomarkers. Participants will receive vital pulp treatment, including partial or full pulpotomy, after caries removal. During treatment, pulpal blood samples will be collected and analyzed using High-Performance Liquid Chromatography to detect metabolic biomarkers. Afterward, a calcium silicate-based material will be placed and the tooth will be restored. Outcomes will be tracked clinically and with X-rays over a 12-month period. Throughout the study, participants will undergo clinical and radiographic assessments to evaluate pulp survival and overall treatment success at 12 months. Researchers will monitor participants from enrollment through the follow-up period to measure the primary outcome of pulp vitality. The total participation time spans from initial treatment through one year of observation to assess long-term results.

Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker