Actively Recruiting
Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker
Led by Abeer Ghalib Abdul-khaliq · Updated on 2026-04-01
60
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.
CONDITIONS
Official Title
Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 16 and 50 years
- Pulp exposure during treatment of deep caries
- No periodontitis or systemic disease
- One or two proximal tooth surfaces lost with remaining walls greater than 2 mm
- Good compliance and signed informed consent form
You will not qualify if you...
- Teeth with large unrestorable defects or need for root canal treatment for aesthetic reasons
- Teeth with negative response to cold testing
- Current pregnancy or breastfeeding
- Poor compliance or inability to complete the trial
- Use of antibiotics, bisphosphonates, or statins within 3 weeks before the study
- Inadequate blood sample collection after pulpal exposure
AI-Screening
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Trial Site Locations
Total: 1 location
1
College of dentistry\ University of Baghdad
Baghdad, Iraq, 964
Actively Recruiting
Research Team
A
Abeer G Abdulkhaliq, master degree
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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