Actively Recruiting
Prediction of Drug Response in Gastric Cancer Based on 3D Bioprinting
Led by Peking Union Medical College Hospital · Updated on 2025-01-24
60
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The therapeutic regimens for adjuvant and neoadjuvant chemotherapy in gastric cancer (GC) predominantly hinge on clinical experience. Consequently, there is an imperative need for preclinical models to facilitate the guidance of individualized medicine. The investigators plan to establish three-dimensional (3D) bioprinted GC models derived from surgically resected tumor tissues of GC patients. These in vitro 3D models will be subjected to treatment with the identical chemotherapy drugs administered to the corresponding patients from whom the models are sourced. The sensitivity of the chemotherapy drugs will be assayed within the in vitro models, and the actual response to chemotherapy in patients will be meticulously evaluated. This observational study aims to substantiate the potential utility of 3D bioprinted tumor models in prognosticating the response to chemotherapy in GC.
CONDITIONS
Official Title
Prediction of Drug Response in Gastric Cancer Based on 3D Bioprinting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- More than 18 years old
- Diagnosed with gastric cancer or confirmed by pathology after surgery
- Underwent preoperative imaging including plain and contrast-enhanced CT scans of chest, abdomen, pelvis, and gastric MRI for tumor staging
- Planned for preoperative (neoadjuvant) or postoperative (adjuvant) chemotherapy after multidisciplinary team discussion
- Able to understand the research protocol and willing to provide written informed consent
You will not qualify if you...
- History of other malignancies or serious medical conditions
- Unable to provide independent informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
Research Team
H
HuaYu Yang, PhD
CONTACT
L
LiWei Du, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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