Actively Recruiting
Prediction of Effectiveness of rTMS Application in Alzheimer's Patients
Led by Istanbul Medipol University Hospital · Updated on 2025-05-02
40
Participants Needed
1
Research Sites
201 weeks
Total Duration
On this page
Sponsors
I
Istanbul Medipol University Hospital
Lead Sponsor
B
Bezmialem Vakif University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Since pharmacological methods are insufficient in the treatment processes of Alzheimer's disease, non-pharmacological methods such as Transcranial Magnetic Stimulation (TMS) have started to be tried as a treatment option as in other neurological and psychiatric diseases. Repeated (rTMS) offers a potential treatment pathway for neurological and psychiatric illnesses. rTMS benefit rate may vary depending on many factors such as the region where it is applied, the progression and the disease degree. The possible effects of TMS on Alzheimer's pathophysiology and modification of disease process (neuroprotective, anti-inflammatory and antioxidant) will also be revealed through blood samples taken from patients before and after treatment. These approaches also constitute the original value of our study.
CONDITIONS
Official Title
Prediction of Effectiveness of rTMS Application in Alzheimer's Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with clinical Alzheimer's Disease using NINCDS-ADRDA criteria
- Age over 55 years
- Clinical Dementia Rating Scale (CDR) score between 1 and 2
- No other diseases affecting cognitive functions
- Volunteer to participate in the study
You will not qualify if you...
- Participant or relative does not give consent
- Unable to participate in entire study procedures (e.g., living in another city)
- History of head trauma with alcohol or substance abuse
- Severe stroke or other neurological sequelae disease
- Metal implant on the head, pacemaker, or contraindications for TMS
- Use of investigational drugs or neuromodulation treatments (e.g., tDCS, TMS) targeting Alzheimer's disease within 1 month before or during the study, except standard treatments such as acetylcholine esterase inhibitors and memantine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medipol University Hospital
Istanbul, Turkey (Türkiye), 34214
Actively Recruiting
Research Team
L
Lutfu Hanoglu, Prof. DR. MD
CONTACT
C
Cennet Sena Parlatan, PhD Cand
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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